Fantasy Football Roundtable: Bold Predictions For Week 6

The Yahoo Fantasy Football crew reveals their boldest takes for Week 6. Check out what Scott Pianowski, Matt Harmon, Ray Garvin, Justin Boone and Joel Smyth have to say.

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Chase Brown will finish as a top-10 RB in Week 6

Joe Flacco steps in as the Bengals’ starter and this is exactly the kind of quarterback Chase Brown needs. In his four starts with Cleveland in 2025, Flacco led the league in short targets (79) and ranked second in RB short targets (32), behind only the 49ers. That’s a massive opportunity shift. Flacco, even at his age, will get the ball out quicker than Jake Browning ever did and lean heavily on his backs in the passing game. That’s where Brown thrives.

Now he gets a Green Bay defense that ranks tied for fifth-worst in Time To Throw allowed, giving quarterbacks 2.90 seconds on average to operate. That extra time is a gift for a non-mobile QB like Flacco, who doesn’t need long to abandon the plan and dump it off to Brown underneath.

This is the best setup he’s had all season. Expect him to deliver a top-10 fantasy week. — Ray Garvin

Green Bay D/ST to have a day vs. Bengals

Defensive touchdowns generally are more fluke-driven than process-driven, but the rules are different in Green Bay this week. Yes, Joe Flacco has already beaten the Packers, but it wasn’t due to his passing skill (142 yards that day, and a puny 3.9 YPA). Now he’s the new kid in town, tied to a horrible Cincinnati offensive line and trying to fast-track a new scheme into his head. Green Bay is a two-touchdown favorite for good reason, and I’m calling the shot — the Packers will not only have multiple sacks and takeaways in this game, but they’ll also score a touchdown on defense. This is one week I’m not afraid to pay up for my defense in DFS games. — Scott Pianowski

Tetairoa McMillan fully breaks out with multiple touchdowns

Through five games, the Panthers' first-round WR ranks seventh in targets and 13th in receiving yards entering Week 6, but is tied for last with zero scores. The prototypical red-zone threat plays for the team leading the league in red-zone passing attempts, as Bryce Young has tossed all seven of his touchdowns this season inside the 20.

McMillan is just the third WR to start his career with five straight games of 8+ targets. The volume is there, the talent is there and the Panthers get the perfect matchup for everything to come together. Not only is Dallas last versus fantasy WRs this season, but it has gotten there by allowing the most receiving touchdowns to wideouts this year. — Joel Smyth

Keenan Allen posts his first top-10 finish of the season

Everybody’s excited about a potential Ladd McConkey resurgence, but it was Keenan Allen who led the Chargers’ passing game with a 29% target share against the Commanders. And that was with Justin Herbert attempting his second-fewest passes of the season (29). Now, the team will be without both starting running backs and a makeshift offensive line. We should expect them to lean on the passing game against a Dolphins’ defense that’s allowed a multi-touchdown performance to every QB they’ve faced.

And, most importantly, opposing passing games have found the most success targeting Miami’s defensive interior (seventh-lowest EPA per play allowed to the slot, tied for fourth-most TDs allowed). Allen’s been the team lead in passing opportunities in three of five games and Herbert’s go-to guy in obvious passing situations. With L.A. poised to lean on their QB to stay atop the AFC West, Allen will get the volume to be a top-10 receiver in Week 6. — Chris Allen

Caleb Williams throws 3+ touchdowns in Week 6

The Bears come off their Week 5 bye to face a Commanders defense that’s had issues defending the pass, and they’ve been particularly vulnerable in ways that this offense can attack. Dan Quinn wants to lean into man coverage but because of poor corner play outside, they’ve lightened the amount of man they’re playing. When they get into zone coverage, they allow the third-highest points per dropback among all NFL defenses, per Fantasy Points Data. They noticeably struggle when teams use motion, particularly motion at the snap.

The Bears specialize in those plays and the Commanders' corners really struggle to pass off routes. Ben Johnson should have plenty of plays dialed up to take advantage and Williams was starting to stack solid moments prior to the bye. I think he throws at least three scores in what will be a high-flying, fantasy-friendly affair between two good offenses and vulnerable defenses. — Matt Harmon

Kendrick Bourne turns in another top-12 WR finish

Bourne was outstanding while serving as the 49ers’ No. 1 receiver in Week 5. The veteran played a season-high 81% of the snaps, turning his 11 targets into 10 catches and 142 yards against the Rams. He’s going to be asked to handle a bigger role once again, with Ricky Pearsall (knee) not expected to be in the lineup and Jauan Jennings’ (ankle/ribs) status up in the air.

Even if Jennings suits up, it doesn’t seem like he’ll be anywhere close to 100%. While the Buccaneers have been slightly better against the pass this season, they’ve still allowed eight different wideouts to post at least 50 yards and/or a touchdown against them — including two top-12 results in the last three weeks. With Mac Jones looking more than competent as a temporary replacement for Brock Purdy, Bourne is about to make fantasy managers who picked him up very happy for a second straight week. — Justin Boone